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Meperidine hydrochloride is a white crystalline substance with a melting point of 186° C to 189° C. It is readily soluble in water and has a neutral reaction and a slightly bitter taste. The solution is not decomposed by a short period of boiling. The tablets contain 50 mg or 100 mg of DEMEROL brand of meperidine hydrochloride. Inactive Ingredients: Calcium Sulfate, Dibasic Calcium Phosphate, Starch, Stearic Acid, Talc.

Dosage and Administration

-diluted to10 mL with sterile water for injection or NS; maximum concentration 10 mg/mL; administer slowly over at least 1 minute

– in 50 mL IV solution over 15 to 30 minutes

– in 50 mL IV solution over 15 to 30 minutes


It is a pain killer drug. Demerol is used to help relieve moderate to severe pain. It may also be used before and during surgery or other procedures.

Side Effects

Common site effects:

Or pain


-Concomitant use of monoamine oxidase inhibitors (MAOIs) or within 14 days of having taken an MAOI.
-Known or suspected gastrointestinal obstruction, including paralytic ileus.
-Hypersensitivity to meperidine or to any other ingredients of the product.
-Significant respiratory depression.
-Acute or severe bronchial asthma in an unmonitored setting or in absence of resuscitative equipment.


Meperidine should not be used for treatment of chronic pain. Meperidine should only be used in the treatment of acute episodes of moderate to severe pain. Prolonged meperidine use may increase the risk of toxicity (e.g. seizures) from the accumulation of the meperidine metabolite, normeperidine. DEMEROL is an opioid agonist and a Schedule II controlled substance with an abuse liability similar to morphine. DEMEROL can be abused in a manner similar to other opioid agonists, legal or illicit. This should be considered when prescribing or dispensing DEMEROL in situations where the physician or pharmacist is concerned about an increased risk of misuse, abuse, or diversion. Wiki

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